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Publikationen (nach 2000)

The Human G Protein-Coupled ATP Receptor P2Y11 Is Associated With IL-10 Driven Macrophage Differentiation Georg Gruenbacher, Hubert Gander, Andrea Rahm, Gabriele Dobler, Astrid Drasche, Jakob Troppmair, Walter Nussbaumer, Martin Thurnher.
Front Immunol 2019 https://doi.org/10.3389/fimmu.2019.01870
Rare, but Severe: Vasculitis and Checkpoint Inhibitors
Andrea Katharina Lindner, Georg Gruenbacher, Gert Schachtner, Martin Thurnher*, Renate Pichler *Eur Urol Focus 2019 https://doi.org/10.1016/j.euf.2019.04.014
*shared senior authorship

Gruenbacher G, Thurnher M. Mevalonate Metabolism in Cancer Stemness and Trained Immunity. Front Oncol. 2018 Sep 20;8:394. doi: 10.3389/fonc.2018.00394. eCollection 2018.

Gruenbacher G, Thurnher M. Mevalonate Metabolism in Immuno-Oncology. Front Immunol. 2017 Dec 1;8:1714. doi: 10.3389/fimmu.2017.01714. eCollection 2017.

Gruenbacher G, Thurnher M. Mevalonate metabolism governs cancer immune surveillance. Oncoimmunology. 2017 Jul 27;6(10):e1342917. doi: 10.1080/2162402X.2017.1342917. eCollection 2017.

Pichler R, Gruenbacher G, Culig Z, Brunner A, Fuchs D, Fritz J, Gander H, Rahm A, Thurnher M. Th2 Predisposition translates into a Th1 Functional Phenotype in Clinical Response to Intravesical BCG in Bladder Cancer (2016) Cancer Immunol Immunother 2017 Apr;66(4):427-440. doi: 10.1007/s00262-016-1945-z. Epub 2016 Dec 22

Theresa Eder, Anja Weber, Hannes Neuwirt, Georg Grünbacher, Christian Ploner, Helmut Klocker, Natalie Sampson, Iris Eder. Cancer-associated fibroblasts diminish the anti-androgen response of prostate cancer cells in 3-dimensional organoid culture. Int J Mol Sci, in press

Thurnher M. Small drops get fat: unexpected fatty acid in cytoplasmic lipid droplets. Cell Chem Biol 2016 23(6):637-8.

Gruenbacher G, Gander H, Rahm A, Idzko M, Nussbaumer O, Thurnher M. The Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens. Cell Reports 2016 (16)30728-8

Thurnher M, Gruenbacher G. T lymphocyte regulation by mevalonate metabolism. Sci Signal. 2015 Mar 31;8(370). Review.

Georg Gruenbacher, Oliver Nussbaumer, Hubert Gander, Bernhard Steiner, Nicolai Leonhartsberger & Martin Thurnher. Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism. Oncoimmunology, Volume 3, Issue 8, 2014

Gruenbacher G, Thurnher M. Mevalonate metabolism in cancer. Cancer Lett. 2015 Jan 28;356(2 Pt A):192-6. doi: 10.1016/j.canlet.2014.01.013. Epub 2014 Jan 24. Review.

Nussbaumer O, Gruenbacher G, Gander H, Komuczki J, Rahm A, Thurnher M. Essential requirements of zoledronate-induced cytokine and γδ T cell proliferative responses. J Immunol. 2013 Aug 1;191(3):1346-55. doi:10.4049/jimmunol.1300603.

Thurnher M, Gruenbacher G, Nussbaumer O. Regulation of mevalonate metabolism in cancer and immune cells. Biochim Biophys Acta. 2013 Jun;1831(6):1009-15. doi:10.1016/j.bbalip.2013.03.003

Thurnher M, Nussbaumer O, Gruenbacher G. Novel aspects of mevalonate pathway inhibitors as antitumor agents. Clin Cancer Res. 2012 Jul 1;18(13):3524-31. doi:10.1158/1078-0432.CCR-12-0489. Review.

Leonhartsberger N, Ramoner R, Falkensammer C, Rahm A, Gander H, Höltl L, Thurnher M. Quality of life during dendritic cell vaccination against metastatic renal cell carcinoma. Cancer Immunol Immunother. 2012 Sep;61(9):1407-13. doi:10.1007/s00262-012-1207

Nussbaumer O, Gruenbacher G, Gander H, Thurnher M. DC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes. Blood. 2011 Sep 8;118(10):2743-51. doi:10.1182/blood-2011-01-328526

Gruenbacher G, Gander H, Nussbaumer O, Nussbaumer W, Rahm A, Thurnher M. IL-2 costimulation enables statin-mediated activation of human NK cells,preferentially through a mechanism involving CD56+ dendritic cells. Cancer Res. 2010 Dec 1;70(23):9611-20. doi: 10.1158/0008-5472.CAN-10-1968. .

Falkensammer CE, Thurnher M, Leonhartsberger N, Ramoner R. C-reactive protein is a strong predictor for anaemia in renal cell carcinoma: role of IL-6 in overall survival. BJU Int. 2011 Jun;107(12):1893-8. doi:10.1111/j.1464-410X.2010.09817.x.

Martin Thurnher. Dendritic cell vaccines. In: Allergy Frontiers, Springer Tokyo Berlin Heidelberg New York 2010.

Serum IgG against Candida predict survival in patients with metastatic renal cell carcinoma. Ramoner R, Rahm A, Falkensammer CE, Leonhartsberger N, Thurnher M. Cancer Immunol Immunother. 2010 Aug;59(8):1141-7. doi:10.1007/s00262-010-0827-z

Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy. Romani N, Thurnher M, Idoyaga J, Steinman RM, Flacher V. Immunol Cell Biol. 2010 May-Jun;88(4):424-30. Epub 2010 Apr 6. Review..

Gruenbacher G, Gander H, Rahm A, Nussbaumer W, Romani N, Thurnher M. CD56+ human blood dendritic cells effectively promote TH1-type gammadelta T-cell responses. Blood. 2009 Nov 12;114(20):4422-31. doi: 10.1182/blood-2009-06-227256.

Ramoner R, Rahm A, Gander H, Stollenwerk B, Falkensammer C, Leonhartsberger N, Thurnher M. Serum antibodies against Saccharomyces cerevisiae: a new prognostic indicator in metastatic renal-cell carcinoma. Cancer Immunol Immunother. 2008 Aug;57(8):1207-14. doi: 10.1007/s00262-008-0454-0.

Putz T, Ramoner R, Gander H, Rahm A, Bartsch G, Bernardo K, Ramsay S, Thurnher M. Bee venom secretory phospholipase A2 and phosphatidylinositol-homologues cooperatively disrupt membrane integrity, abrogate signal transduction and inhibit proliferation of renal cancer cells. Cancer Immunol Immunother. 2007 May;56(5):627-40. Epub 2006 Sep 1.

Kleinrath T, Gassner C, Lackner P, Thurnher M, Ramoner R. Interleukin-4 promoter polymorphisms: a genetic prognostic factor for survival in metastatic renal cell carcinoma. J Clin Oncol. 2007 Mar 1;25(7):845-51.

Leonhartsberger N, Ramoner R, Putz T, Gander H, Rahm A, Falkensammer C, Bartsch G, Thurnher M. Antigen-independent immune responses after dendritic cell vaccination. Cancer Immunol Immunother. 2006 Nov 15; [Epub ahead of print].

Thurnher M. Lipids in dendritic cell biology: messengers, effectors, and antigens. J Leukoc Biol. 2007 Jan;81(1):154-60. Epub 2006 Sep 13. Review.

Thomas Putz, Reinhold Ramoner, Hubert Gander, Andrea Rahm, Georg Bartsch, and Martin Thurnher. Antitumor action and immune activation through cooperation of bee venom secretory phospholipase A2 and phosphatidylinositol-(3,4)-bisphosphate. Cancer Immunology and Immunotherapy. 2006 Feb 17; [Epub ahead of print].

Falkensammer C., Jöhrer K.,  Gander H., Rahm A., Ramoner R., Putz T., Greil R., Bartsch G., and Thurnher M. IL-4 inhibits the TNF-alpha induced proliferation of renal cell carcinoma (RCC) and cooperates with TNF-alpha to induce apoptotic and cytokine responses by RCC: implications for antitumor immune responses. Cancer Immunology and Immunotherapy. 2006 Jan 28; [Epub ahead of print].

Bektic J, Pfeil K, Berger AP, Ramoner R, Pelzer A, Schafer G, Kofler K, Bartsch G, Klocker H. Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. Prostate. 2005; 64:332-40.

Doehn C., Jocham D., Bartsch G., and Thurnher M. Nierenzellkarzinom. In: Krebsimmuntherapien. Eds. Huber C. and Rammensee H-G. Ärzteverlag 2005.

Martin Thurnher, Thomas Putz, Andrea Rahm, Hubert Gander, Reinhold Ramoner, Georg Bartsch, Lorenz Höltl and Claudia Falkensammer. Therapeutic applications of dendritic cells in cancer: renal cell carcinoma. In: Dendritic cells. Eds. Steinkasserer, Romani, Schuler. Wiley Verlag 2005.

Joseph H. Coggin Jr., Adel L. Barsoum, James W. Rohrer, Martin Thurnher, Matthias Zeis and Paul O. Schwarzenberger. Cancer Vaccine Technology Update: The Immunobiology of 37 kDa Oncofetal Antigen/Immature Laminin Receptor Protein [OFA/iLRP], a Universal Tumor Immunogen. Modern Aspects in Immunobiology 2005; 16:27-34.

Joseph H. Coggin, Jr., Adel L. Barsoum, James W. Rohrer, Martin Thurnher, and Matthias Zeis. Contemporary Definitions of Tumor Specific Antigens, Immunogens, and Markers as Related to the Adaptive Responses of the Cancer-Bearing Host. Anticancer Research 2005; 25:2345-55.

Karin Jöhrer, Claudia Zelle-Rieser, Alexander Perathoner, Martina Hager, Patrizia Moser, Reinhold Ramoner, Hubert Gander, Lorenz Höltl, Georg Bartsch, Richard Greil and Martin Thurnher. 2005. Upregulation of functional chemokine receptor CCR3 in kidney cancer. Clinical Cancer Research 2005; 11:2459-65.

Martin Thurnher, Thomas Putz, Hubert Gander, Andea Rahm, Georg Bartsch and Reinhold Ramoner. 2005. The cyclopentenone prostaglandin PGA2 co-stimulates the TNF-alpha induced maturation of human dendritic cells. Experimental Hematology. 33:144-150.

Thomas Putz, Hubert Gander, Reinhold Ramoner, Claudia Zelle-Rieser, Andrea Rahm, Walter Nußbaumer, Georg Bartsch, Lorenz Höltl and Martin Thurnher. 2004. Generation of clinical grade dendritic cells using the CliniMACS system. Methods in Molecular Medicine, 2005; 109: 71-82.

Herwig, R., Horninger, W., Klocker, H., Ramoner, R., Thurnher, M., Rehder, P., Konwalinka, G., and Bartsch, G. 2005. Ability of PSA-positive circulating macrophages to detect prostate cancer. The Prostate, 62: 290-8.

Thomas Putz, Reinhold Ramoner, Hubert Gander, Andrea Rahm, Georg Bartsch, Lorenz Höltl and Martin Thurnher. 2004. Monitoring of immune responses after dendritic cell based immunization using CFSE dye dilution analysis. Journal of Clinical Immunology, 24:653-63.

Reinhold Ramoner, Thomas Putz, Hubert Gander, Andrea Rahm, Georg Bartsch, Claudia Schaber and Martin Thurnher. Dendritic cell activation by secretory phospholipase A2. Blood. 2004 Oct 19; Epub ahead of print.

Lorenz Höltl, Reinhold Ramoner, Claudia Zelle-Rieser, Hubert Gander, Christine Papesh, Walter Nussbaumer, Georg Bartsch and Martin Thurnher. Allogeneic dendritic cell vaccination against metastatic renal cell carcinoma with or without cyclophosphamide. Cancer Immunology and Immunotherapy. 2004 Dec 17; Epub ahead of print.

Höltl, L., Zelle-Rieser, C., Gander, H., Papesh, C., Ramoner, R., Georg Bartsch, Rogatsch, H., Barsoum, A.L., Coggin, J.H. Jr., and Thurnher, M. 2002 (Nov). Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin. Cancer Res. 8:3369 - 3376.

Schmidhammer, S., Ramoner, R. Höltl, L., Bartsch, G., Thurnher, M. and Zelle-Rieser, C. 2002 (Sep). An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells. Urology, 60:521-526.

Nigou, J., Gilleron, M., Rojas, M., García, L.F., Thurnher, M., and Puzo, G. 2002 (Jul) Mycobacterial lipoarabinomannans: modulators of dendritic cell function and apoptotic response. Microbes and Infection, 4:945 - 953.

Heitger, A., Winklehner, P., Eder, J., Zelle-Rieser, C., Kropshofer, G., Obexer, P., Thurnher, M., and Holter, W. 2002 (Jun). Defective T-helper cell function after T-cell depleting therapy affecting naive and memory populations. Blood, 99:4053 - 4062.

Zelle-Rieser, C., R. Ramoner, E. Artner-Dworzak, A. Casari, G. Bartsch, M. Thurnher. 2002 (Jan). Human monocyte-derived dendritic cells are deficient in prostaglandin E2 production. FEBS Lett, 511:123 – 126.

Nigou, J., M. Gilleron, C. Zelle-Rieser, M. Thurnher, and G. Puzo. 2001 (Jun). Molecular basis of the lipoarabinomannan capacity to modulate interleukin-12 secretion by human dendritic cells. J Immunol, 166:7477-85.

Zelle-Rieser C., Barsoum, A. L., Ramoner, R., Rohrer, J. W., Coggin, J. H., Jr, Höltl, L., Bartsch, G. and M. Thurnher. 2001 (May). Expression and immunogenicity of oncofetal antigen / immature laminin receptor in human renal cell carcinoma. J Urol, 165:1705-1709.

Thurnher, M., C. Zelle-Rieser, R. Ramoner, G. Bartsch, Höltl L. 2001 (Apr). The disabled dendritic cell. FASEB J, 15:1054-1061.

Thurnher, M., and Zelle-Rieser, C. 2001 (Apr). Deficiency in eicosanoid production may limit the therapeutic efficacy of human monocyte-derived dendritic cells. Mod. Asp. Immunobiol., 2(2):58-61.

Zelle-Rieser, C., R. Ramoner, G. Bartsch, M. Thurnher. 2000 (Feb). A clinically approved oral vaccine against pneumotropic bacteria induces the terminal maturation of CD83+ human dendritic cells. Immunol Lett, 76:63-67.

Boesch ST, Dobler G, Ramoner R, Corvin S, Thurnher M, Bartsch G, Klocker H. 2000 Effects of alpha1-adrenoceptor antagonists on cultured prostatic smooth muscle cells. Prostate Suppl, 9:34-41.